Since the new coronavirus COVID-19 entered the world stage, doctors and scientists have been searching for an effective treatment and an effective vaccine capable of preventing it. Meanwhile, the approach that each patient takes will be decisive in their evolution.
At this point, there are not a few who consider that “to optimize the treatment of the disease, it is necessary to understand the pathophysiological mechanism that originates the SARS-CoV-2 infection”.
“This mechanism seems to be especially complex, urging the discipline of clinical research to work to unravel many of the aspects that underlie the particular manifestations of the disease.” As specified to Infobae the internal medicine specialist and pulmonologist Alexis Doreski (MN 141740) “first, it should be noted that the stage of viral replication is in most cases limited and does not extend beyond 10 to 12 days after the onset of symptoms, finding the highest viral load at the onset of symptoms”.
The director of clinical research and one of the founders of Breathing Foundation He explained that “this first viral phase may be confined to the upper airways or extend to the lung, causing a picture of acute interstitial pneumonia.” “As the immune response is launched, there is an abrupt decrease in viral replication, giving way to the second phase or inflammatory phase,” said the specialist. This is a crucial stage in the progression of the disease since if the patient develops a moderate inflammatory response, in the vast majority of cases it evolves favorably”.
Is that when SARS-CoV-2 enters the cell, “from that moment it begins to duplicate its genetic material with the aim of dividing, amplifying and generating new particles,” biologist and doctor of science Federico delved into this medium Prada. “Once it has finished replicating, it has to go out, break the cell where it is and that is where an alarm goes off in the immune system – if it was not previously detected.” At that time, numerous cells of the immune system begin to arrive at the site and this generates an inflammation and the inflammation brings with it an increase in temperature, blood supply to the area and in many cases an arrival of many cells from the bloodstream to the tissue. affected“Said the director of the Bachelor of Bioinformatics and Bachelor of Biotechnology at the Universidad Argentina de la Empresa (UADE), who described what happens next as” a true battle at the immune level between defense cells and the virus that is it’s spreading. ”
However, it should be remembered that the quality and intensity of the inflammatory response “varies from one individual to another according to the state and characteristics of each person’s immunity.” “Furthermore, the presence of certain comorbidities such as advanced age, diabetes, smoking, high blood pressure and obesity itself implies a factor of poor prognosis,” added Doreski-. When these conditions converge, a hyperinflammatory response is triggered, resulting in a moderate to severe condition. ”
At this point, for him, “If you lose the ability to regulate the magnitude of this response, you enter phase 3, or hyperinflammatory phase, characterized by a cascade of events that together is called ‘cytokine storm’, but is currently under discussion”.
“What is globally accepted is that there is systemic inflammation,” said the specialist, for whom “the possibility of administering systemic anti-inflammatory treatment early or directly to biophase (to the lung) through nebulization or inhalation at the beginning of the inflammatory phase could interrupt its progression towards the hyperinflammatory phase ”.
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