Geneva. The World Health Organization (WHO) said Saturday that it stopped its trials with hydroxychloroquine and a combination of two HIV drugs – lopinavir and ritonavir – in patients hospitalized for Covid-19, because they failed to reduce the rate of mortality.
The announcement occurs on the same day that the WHO reported more than 210,000 cases of coronavirus globally in a single day, setting a new record since the beginning of the epidemic. The United States accounted for about 25% of those new infections, the agency said.
“The preliminary results of the hydroxychloroquine and lopinavir / ritonavir trials produce little or no reduction in the mortality of hospitalized patients with Covid-19 when compared to standard treatment. The investigators will discontinue these trials with immediate effect,” the agency said. it’s a statement.
The UN agency said the decision, made on the recommendation of the international steering committee that oversees the trials, does not affect other studies in which those drugs have been used in outpatients or as prophylaxis.
Another branch of the WHO-led trial is looking at the possible effect of Gilead’s antiviral drug remdesivir in patients infected with Covid-19. The European Commission approved the use of remdesivir conditionally on Friday after demonstrating that it shortens hospital recovery times.
The WHO trial, which brought together scientists from various parts of the world, addresses five branches examining possible treatment approaches for Covid-19: standard care; remdesivir; hydroxychloroquine; the lopinavir / ritonavir cocktail; and lopanivir / ritonavir combined with interferon.
WHO Director-General Tedros Adhanom Ghebreyesus told reporters on Friday that nearly 5,500 patients in 39 countries had so far been recruited for clinical trials and that provisional results were expected in two weeks.
About 18 experimental vaccines for Covid-19 are being tested in humans among nearly 150 treatments in development.
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