Coronavirus, Chinese phase 2 vaccine stimulates the immune response

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Coronavirus, Chinese phase 2 vaccine stimulates the immune response







© Provided by Corriere della Sera



It stimulates the immune system’s response against the novel coronavirus, but it is still unclear whether it will effectively protect against infection. These are, in summary, the preliminary results of the tests for the vaccine candidate Chinese anti Covid-19 «BBIBP-CorV». The phase 1-2 trial was conducted in China from 29 April to 30 July on over 600 healthy volunteers between 18 and 80 years old. Various institutions are involved, including the Henan Provincial Center for Disease Control and Prevention and the Beijing Institute of Biological Products. The data was published in the journal The Lancet Infectious Diseases. The study highlighted one antibody response in all participants, with different times according to age: 42 days for the over 60s compared to 28 days for people in the 18-59 age group. Furthermore, the levels of antibodies recorded in the elderly are lower than those developed by the young. This last figure is not surprising, given that the immune system becomes weaker with age. In phase 1-2 it has not yet been adequately assessed whether the antibody response induced by the vaccine candidate is sufficiently protective against SarsCov2 infection. You will understand this at the end of phase 3.

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Back in the polls, with Steve Bannon just indicted for fraud, gossip about disagreements with Melania, fierce criticism of sister former federal judge and latest tile of Kellyanne Conway's abandonment, the Republican Convention begins today uphill for Donald Trump. the scenes of the virtual congress due to the coronavirus pandemic that starts today in Charlotte, there are two producers of The Apprentice, the reality show that transformed Donald Trump into a television star. These are Sadoux Kim, long-time deputy to Mark Burnett, the show's creator, and Chuck Labella, who handled talent on the same show. both also worked for the Miss Universe pageant when it was owned by the tycoon, the former also as a judge of the contestants. The two are consultants to the organizing team and have already been paid by the Republican party respectively 54,000 and 81,000 dollars. 'One man show' Donald Trump will naturally be the absolute star of the show which kicks off tonight at 8.30pm (2.30am in Italy) in Charlotte, North Carolina, and will officially crown the American president for the race to a second term in the elections November 3 in the United States. Forced by the pandemic to hold an almost entirely virtual conclave, the head of the White House will not have the electrifying crowds he loves but will take advantage of every moment to use all the artillery against his rival, Joe Biden, just invested in the Democratic convention. Trump will speak every evening around 10 pm (4 am in Italy), according to what was anticipated by the New York Times which observed that it is a tear from the convention tradition that wants the 'nominated' to intervene only for a greeting at the opening and the speech of thanks on the final day. On the day of the "Promise land" the president will be in person at the convention center that hosts the event in Charlotte, North Carolina and which will start with the number of 336 delegates from the 50 states of the country to name him, a 'roll call' that the Grand Old Party wanted to be in person despite the coronavirus emergency. The other highlight will be on the final day, Thursday, when he delivers his acceptance speech from the White House Garden, a privileged setting that critics say blurs the traditionally respected boundaries between the president's duties and the candidate's campaign. But Trump assured that doing it there was the safest and cheapest for the country and that, after all, that is still the "your" House: "It is a place that makes me feel good, it makes the country feel good"he told the New York Post. The program Little is known about the program, except that Wednesday the day (entitled the "Land of heroes") will be the time of the vice president, Mike Pence, for his reconfirmation. He will speak from Fort McHenry, a historic enclave near Baltimore, a sacred place for American independence. Tuesday (day dedicated to "Land of opportunities") instead the First lady, Melania Trump, will speak from the iconic rose garden of the White House. The model who arrived from Slovenia in the mid-1990s will try to make people forget the role of 2016, when her message before the Republican National Convention was accused of plagiarizing entire passages of Michelle Obama's speech in 2008 Her words are now eagerly awaited , not only because of the First Lady's usual low profile, but because days ago her refusal to take her husband's hand upon descent from Air Force One raised suspicions of tensions within the presidential couple. Other members of the Trump family, most notably eldest daughter and adviser Ivanka, will feature prominently on Tuesday, as well as allies of the president, such as minority leader in the House of Representatives, Kevin McCarthy, and former states ambassador. United with the UN, Nikki Haley. Also on the list of special guests are Patricia and Mark McCloskey, transformed into heroes of the right after being filmed wielding firearms at a group of protesters marching in St. Louis in full crisis for the killing of George Floyd. Nicholas Sandmann, a recent Catholic graduate who became famous in 2019, could also intervene when, sporting a baseball cap with the Trump slogan "Make America Great Again", appeared in the media while making fun of an indigenous elder during a school visit to Washington. The nomination comes not at the best of times for Trump. Again, the former tycoon's image is clouded by the words of his sister, former federal judge Maryanne Trump Barry, who defined him "cruel", "liar", "without principles" and therefore "unreliable" and claimed he would get into the University of Pennsylvania by having someone else take the entrance test for him. The judgments are contained in some recordings made secretly by her niece Mary Trump, author of a book-denunciation against the president, and disseminated exclusively by the Washington Post.

The other candidates

There are 182 vaccine candidates in the early stages of evaluation. For ‘BBIBP-CorV’, stocks of the virus were grown in the laboratory using cell lines from an isolated patient sample. Then they were inactivated thanks to a particular chemical compound. Another component was later added, aluminum hydroxide, known to enhance the immune response. At the moment a few dozen vaccine candidates I am in phase 3, the most advanced, or about to enter. Carlo Federico Perno, virologist and director of the Microbiology Unit at the Bambino Gesù Children’s Hospital in Rome, in a recent interview al Courier service explained that many of these preparations stimulate the production of large quantities of antibodies, capable of neutralizing the coronavirus, but for all real effectiveness has yet to be demonstrated against the disease. “In phase 3, called registration, we check whether the vaccine candidate really has the ability to protect us,” says Perno. The preparation is administered to a sample of people considered at risk for the possibility of contracting the infection. Then the results are compared with those of another sample, which can be given a “placebo” or nothing. It is thus possible to demonstrate whether the candidate vaccine really functions as a “shield” against the virus. Only at that point can it be defined as a full-fledged vaccine.

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