Vitamin B3 against melanoma. Nicotinamide (Nam), known, precisely, as vitamin B3 or vitamin PP, has been shown to be able, in a study published in the Journal of Experimental and Clinical Cancer Research, to reduce the number of skin melanoma cells by up to 90%, reducing in vitro growth and increasing death. Nam also significantly delayed tumor growth in vivo and improved survival of mice with melanoma, indicating a possible key role for the immune response. The research was conducted by the Higher Institute of Health, in collaboration with the Dermopathic Institute of the Immaculate Conception (Idi-Irccs) and the La Sapienza University of Rome.
“Nam, or niacin, is a B vitamin also known for its effectiveness against pellagra,” explain the researchers. “In our in vitro and in vivo experiments it showed a relevant activity against cutaneous melanoma. We also observed that its mechanism of action involves the increase of molecules such as Nad + and Atp and the inhibition of the enzyme Sirt2, whose expression is significantly increased in melanoma and inversely related to patient survival “.
“For the first time we have also shown – continue the researchers – that the expression levels of vitamin B3 receptors are almost completely absent in biopsy tissues of human melanoma compared with those of non-malignant lesions, using data available on online databases relating to more than 1000 people “. Nam is already used in the clinic for the prevention of damage from ultraviolet rays and in the prevention of non-melanoma skin tumors, therefore it is a candidate as a possible anti-melanoma weapon.